How Your GUT Affects Your Immune System

Date: 2020-04-15 15:00:02

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How Your GUT Affects Your Immune System – Thomas DeLauer

Your gut wall contains 70-80% of the cells that make up your immune system – put another way, 70–80% of the body’s immune cells are found in the gut

Intestinal Barrier

The intestinal barrier is made up of epithelial cells that line the gut and inflammatory molecules (cytokines) and antibodies (i.e. IgA)


IgA is a type of antibody that can prevent harmful interactions with the immune system

Artificial Sweeteners & The Gut

A study published in the journal Molecules, researchers found that six common artificial sweeteners approved by the Food and Drug Administration and 10 sport supplements that contained them were found to be toxic to the digestive gut microbes of mice.

The researchers tested the toxicity of aspartame, sucralose, saccharine, neotame, advantame, and acesulfame potassium-k. They observed that when exposed to only 1 milligram per milliliter of the artificial sweeteners, the bacteria found in the digestive system became toxic.

Two big findings: Firmicutes were largely decreased while Bacteroidetes significantly increased AND some key genes, such as butyrate genes, were decreased


A 2019 study, published in PNAS, found that sugar can keep good microbes from colonizing your gut

Researchers found that large doses of fructose and glucose impede the production of proteins that foster the growth of a bacterial species often found in lean, healthy people

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